what is a good triglycerides to hdl ratio?
Cardiorespiratory Fettle, the Triglyceride:HDL Ratio and Coronary Heart Disease Mortality Chance in Men
A while back, we talked about the importance of the blood Triglyceride:HDL ratio. To refresh your memory, nosotros calculate the ratio only by dividing the fasting claret triglyceride level by the claret level of HDL cholesterol. Here's an example: Mark has a fasting blood triglyceride level of 100 mg/dL and an HDL-cholesterol level of 50 mg/dL. His Triglyceride:HDL ratio is 100 / 50 = two. Low ratio values such as this one indicate good insulin sensitivity; which ways that insulin is doing a not bad job helping to move glucose and amino acids from the blood into your cells. Information technology also means that yous have a relatively low take chances of developing prediabetes, blazon 2 diabetes, and metabolic syndrome. Additionally, low ratios indicate that y'all take the relatively innocuous 'large and fluffy' LDL cholesterol type, which makes you less decumbent to coronary center disease (CHD). On the other hand, let's say that your blood triglycerides were 240 mg/dL and your HDL was thirty mg/dL. Some quick math tells the states that the ratio this time is 8. This is a high ratio, suggesting that you lot are insulin resistant. Simply put, fifty-fifty though you lot are producing insulin, also much glucose is remaining in the blood. As a upshot, yous accept a relatively high run a risk of developing prediabetes, type 2 diabetes, and metabolic syndrome. A high ratio likewise tends to signal that you have the more sinister 'small and dumbo' LDL cholesterol type, which makes you more prone to coronary heart disease (CHD) and stroke.
We've known for a few decades that having a moderate to high level of cardiorespiratory fettle (CRF) significantly decreases the gamble of death from CHD as compared to having a depression level of CRF. So with all this in mind, my colleagues and I decided to have a await at all possible combinations of CRF and Triglyceride:HDL ratio values to see how they impacted the adventure of dying from CHD. We studied 40,269 apparently healthy men who underwent a comprehensive concrete exam at the Cooper Clinic betwixt 1978 and 2010. All of the men had a maximal treadmill stress examination and claret piece of work at the time of their examination.
Based on their treadmill test time and age, we divided them into 3 categories of CRF:
Depression fit: men who scored in the lesser 20% (1st quintile) compared to other men in their historic period group.
Moderate fit: men who scored in the next 40% (2nd and 3rd quintile) compared to other men in their historic period grouping.
High fit: men who scored in the meridian 40% (4thursday and 5th quintile) compared to other men in their historic period group.
We also divided the men into four groups according to their Triglyceride:HDL ratio. Remember that the lower the ratio, the lower the run a risk of CHD:
Group ane: Triglyceride:HDL Ratio <i.51
Group two: Triglyceride:HDL Ratio one.51-ii.39
Group 3: Triglyceride:HDL Ratio 2.40-three.90
Group 4: Triglyceride:HDL Ratio >3.xc
The group was then tracked for an average of 16.6 years. During that time, 556 men died from CHD. Non surprisingly, we found that both CRF and Triglyceride:HDL ratio were each very strong and independent predictors of CHD decease. We took it a step further and looked at the risk of expiry in all 12 possible CRF and Triglyceride:HDL ratio combinations; this is shown in the Figure below. Nosotros took historic period, length of follow-up, family history of CHD, and smoking into consideration before doing the analyses. The different bars that you meet in the Figure testify the take chances of CHD death within each CRF-Triglyceride:HDL ratio category; the higher the bar, the higher the risk of death. Equally you can see from the Figure, the lowest run a risk of CHD death was seen in Group 1 men with high levels of CRF, while the highest risk of decease was seen in Group 4 men with low levels of CRF. The novel finding was that within all 4 Triglyceride:HDL ratio groups, nosotros saw the greatest risk of death in low fit men, while the adventure was decreased in moderate fit men, and tended to be the lowest in high fit men. Interestingly, among all Grouping 1 men, those who were low fit were more than twice equally likely to die from CHD every bit high fit men! Then, fifty-fifty though all the men in Group i had depression risk Triglyceride:HDL ratios, their fitness level had a big impact on their risk of dying from CHD during the follow-upward.
The have-home message is that regardless of the Triglyceride:HDL Ratio, men need to attain at least a moderate level of CRF in order to reach the lowest gamble possible. Most men should be able to accomplish this level of CRF by meeting the current public health guidelines for concrete activity: Adults should accumulate at least 150 minutes per week of moderate aerobic activeness or at least 75 minutes per calendar week of vigorous aerobic activity. If achieving significant weight loss or a high level of CRF is the goal, then equally much as 300 minutes per week of moderate, or 150 minutes per week of vigorous aerobic activeness may be necessary. Be sure to beginning slowly and gradually piece of work upwardly to these suggested levels of activity.
Then, the side by side time you have claret work done, calculate your Triglyceride:HDL Ratio if yous do non encounter this value on your study. Retrieve that the higher the ratio, the higher the hazard of developing prediabetes, diabetes, metabolic syndrome, and dying from CHD. It also pays to retrieve that unlike prescription medications, lifestyle changes (i.e. regular physical activity, healthy diet, quitting smoking, and modest weight loss if needed) cost nix and accept no side effects!
References
ane. Lamarche, B., Lemieux, I., Despres, J.P. (1999). The pocket-size dense LDL phenotype and the take a chance of coronary heart disease: epidemiology, pathophysiology, and therapeutic aspects. Diabetes Metab. 25:199-211.
2. Farrell, South.Westward., Finley, C.East., Barlow, C.E., Willis, B.50., DeFina, L.F., Haskell, Due west.L., Vega, Grand.Fifty. (2017). Moderate to high levels of cardiorespiratory fitness attenuate the furnishings of triglyceride to high-density lipoprotein cholesterol ratio on coronary heart disease bloodshed in men. Mayo Clin Proc, 92(12):1763-1771. http://dx.doi.org/10.1016/j.mayocp.2017.08.015
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Source: https://www.cooperinstitute.org/2017/11/28/cardiorespiratory-fitness-the-triglyceridehdl-ratio-and-coronary-heart-disease-mortality-risk-in-men
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